Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccination
This genome-wide association study (GWAS) explores the genetic components of severe adverse events following COVID-19 vaccination, with focus on myocarditis and pericarditis. Three SNPs (rs536572545, rs146289966 and rs142297026) near the SCAF11 gene were linked to pericarditis, while rs570375365 in the LRRC4C gene was associated with myocarditis. These findings suggest that genetic variants may influence inflammation pathways, providing a basis for further investigation into the immunological responses triggered by vaccines.
Authors
- Mia Wadelius (ORCID: https://orcid.org/0000-0002-6368-2622)
- Niclas Eriksson (ORCID: https://orcid.org/0000-0002-2152-4343)
- Ahmet Yalçınkaya (ORCID: https://orcid.org/0000-0002-1172-3330)
- Nils Landegren (ORCID: https://orcid.org/0000-0002-6163-9540)
- Marco Cavalli (ORCID: https://orcid.org/0000-0003-1143-1431)
- Pär Hallberg (ORCID: https://orcid.org/0000-0003-3465-3280)
- Tomasz Baron (ORCID: https://orcid.org/0000-0002-8290-557X)
- Petter Brodin (ORCID: https://orcid.org/0000-0002-8103-0046)
Institutions
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
- Hacettepe University Hospital (TR)
- Stockholm Health Care Services (SE)
- Imperial College London (GB)
Publication Details
- Journal
- npj Vaccines
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1038/s41541-025-01139-4
- Citations
- 1
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Karolinska Institutet
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Akademiska Sjukhuset
- Uppsala Universitet
- Science for Life Laboratory