Treatment Patterns and Survival Among Veterans With De Novo Metastatic Hormone-Sensitive Prostate Cancer
In this cross-sectional study of veterans with de novo mHSPC, use of combination therapies increased over time and were associated with longer survival compared with ADT monotherapy. In both high- and low-volume mHSPC, no differences in OS were observed between ARPI and docetaxel combinations; however, ARPIs had longer PFS. Future research into the role of docetaxel is needed to elucidate the benefit of chemotherapy in mHSPC.
Authors
- Carley Pickett
- Nina Cheranda
- Rohan Agarwal
- Nicholas Fedele
- Saira Khan (ORCID: https://orcid.org/0000-0002-9024-9461)
- Kaitlin Stackable
- Molly K. Wynveen (ORCID: https://orcid.org/0009-0009-9538-7802)
- E Knoche
- Danielle Candelieri-Surette (ORCID: https://orcid.org/0009-0008-8750-6720)
- Forest Riekhof (ORCID: https://orcid.org/0000-0001-5253-5566)
- Bruce Montgomery (ORCID: https://orcid.org/0000-0003-4459-0295)
- Martin William Schoen (ORCID: https://orcid.org/0000-0001-6388-5553)
- Abhinav Rajasekhar
- Ruth Etzioni (ORCID: https://orcid.org/0000-0002-9164-6370)
- Jason M. Doherty (ORCID: https://orcid.org/0000-0003-3142-5805)
- Srinivas Govindan (ORCID: https://orcid.org/0000-0002-0414-7822)
- Priya Baxi
- Krishny Karunanandaa
- Robert Wilson (ORCID: https://orcid.org/0000-0003-3904-9250)
- Daniel B. Eaton (ORCID: https://orcid.org/0000-0001-9819-2159)
- Kara Ingram
Institutions
- University of Washington (US)
- Washington University in St. Louis (US)
- Fred Hutch Cancer Center (US)
- VA Salt Lake City Healthcare System (US)
- VA Puget Sound Health Care System (US)
- VA St. Louis Health Care System (US)
- Saint Louis University (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.9433
- Citations
- 9
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 13.67