Patients with periodontitis exhibit persistent dysbiosis of the gut microbiota and distinct serum metabolome
Gut dysbiosis of periodontitis patients may impact systemic metabolite profiles. Given that periodontal therapy alone did not substantially improve the gut microbiota, adjunctive strategies targeting the gut microbiome may be effective in reducing the risk of periodontitis-associated diseases.
Authors
- Takako Eguchi Nakajima
- Jun Kikuchi (ORCID: https://orcid.org/0000-0002-6809-394X)
- Kazuhisa Yamazaki
- Yuuri Tsuboi
- Kentaro Mizuno (ORCID: https://orcid.org/0000-0002-9624-2009)
- Naoki Takahashi (ORCID: https://orcid.org/0000-0001-8952-7260)
- Shigeru Ono (ORCID: https://orcid.org/0000-0002-9239-4654)
- Hidetoshi Morita
- Nobuo Sasaki (ORCID: https://orcid.org/0000-0002-8798-7244)
- Shujiro Okuda (ORCID: https://orcid.org/0000-0002-7704-8104)
- Hiroshi Ohno (ORCID: https://orcid.org/0000-0001-8776-9661)
- Eiji Miyauchi (ORCID: https://orcid.org/0000-0002-8202-684X)
- Nobuaki Miura (ORCID: https://orcid.org/0000-0001-8891-9190)
- Kentaro Imamura (ORCID: https://orcid.org/0000-0001-6428-3677)
- Kyoko Yamazaki
Institutions
- Tokyo Dental College (JP)
- Okayama University (JP)
- Gunma University (JP)
- Hokkaido University (JP)
- University of Michigan (US)
- RIKEN Center for Sustainable Resource Science (JP)
- Ono Clinic (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- Niigata University (JP)
Publication Details
- Journal
- Journal of Oral Microbiology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1080/20002297.2025.2499284
- Citations
- 10
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 8.06
Funders
- Japan Agency for Medical Research and Development
- Core Research for Evolutional Science and Technology