Pharmacokinetics of Intraperitoneal Lidocaine for Sustained Postoperative Analgesia in Adults
A third of the intraperitoneal dose did not reach the central compartment and absorption took ~2 h. Simulations show that 2 mg/kg/h intraperitoneal infusion achieves a 5-point pain score reduction within ~36 min.
Authors
- Wiremu MacFater (ORCID: https://orcid.org/0000-0002-9323-7036)
- Darren M. Svirskis (ORCID: https://orcid.org/0000-0001-9435-1773)
- Brian J. Anderson (ORCID: https://orcid.org/0000-0002-2826-3019)
- Kent C. Osborne (ORCID: https://orcid.org/0009-0002-4586-8973)
- Andrew Hill (ORCID: https://orcid.org/0000-0001-8672-6379)
- Jacqueline A. Hannam (ORCID: https://orcid.org/0000-0003-2974-7397)
Institutions
- University of Auckland (NZ)
- Middlemore Hospital (NZ)
Publication Details
- Journal
- European Journal of Drug Metabolism and Pharmacokinetics
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1007/s13318-025-00948-1
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Government
- University of Auckland
- Health Research Council of New Zealand