Regulatory Effects of the Wnt7b/β-Catenin/MMP-2 Signaling Pathway on Scleral Stiffness in Guinea Pigs With Form-Deprivation Myopia
The Wnt7b/β-catenin pathway regulates scleral biomechanics by upregulating MMP-2 expression, which leads to increased collagen I degradation and, consequently, an increase in axial elongation and a myopic shift in refractive error.
Authors
- Dongshi Guan (ORCID: https://orcid.org/0000-0002-4433-3662)
- Binyu Wen (ORCID: https://orcid.org/0000-0002-7549-1508)
- Hui Tao (ORCID: https://orcid.org/0000-0002-6493-2101)
- Jiaqi Du (ORCID: https://orcid.org/0000-0003-1592-9093)
- Zhihong Deng (ORCID: https://orcid.org/0000-0001-9926-4943)
- Hong Ren
- Hangyu Li (ORCID: https://orcid.org/0000-0001-5582-3942)
- Jing Zhang (ORCID: https://orcid.org/0000-0003-0792-0486)
- Mengdi Shi
- Ziyi Cai
- Chen Shen (ORCID: https://orcid.org/0000-0002-7806-5723)
- Bosheng Ma
Institutions
- Central South University (CN)
- Chinese Academy of Sciences (CN)
- Third Xiangya Hospital (CN)
- Institute of Mechanics (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1167/iovs.66.5.19
- Citations
- 3
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences