Is Serum Tryptase a Dependable Biomarker for Diagnosing and Tracking Rheumatoid Arthritis?

Aim: Our aim in this study was to demonstrate that rheumatoid arthritis (RA) patients have an increase in serum tryptase concentrations and that this correlates with the level of disease activity. Material and Method: The research involved 43 patients RA and 37 healthy participants as the control group. The average ages of the patients and the control group were 52.53±11.10 and 48.41±12.79 years, respectively. Sociodemographic information of all participants was recorded. Disease Activity Score 28 (DAS28), Health Assessment Questionnaire (HAQ) and Visual Analog Scale (VAS) scores were calculated after detailed examination to determine disease activity. Total serum tryptase concentrations were evaluated using enzyme-linked immunosorbent assay (ELISA). Results: Serum tryptase levels were higher in the RA group compared to the healthy group and a statistically significant difference was found (p