(R)-ketamine induces mGlu5 receptor-dependent antidepressant-like effects in the chronic unpredictable mild stress model of depression in mice
The weakening of mGlu<sub>5</sub> receptor function in the hippocampus appears to be related to the (R)-ketamine antidepressant-like effect, and coadministration of the partial mGlu<sub>5</sub> receptor NAM, M-5MPEP, might increase its antidepressant activity.
Authors
- Paulina Pabian (ORCID: https://orcid.org/0000-0002-3449-5318)
- Agata Faron‐Górecka (ORCID: https://orcid.org/0000-0002-8202-190X)
- Katarzyna Kaczorowska (ORCID: https://orcid.org/0000-0001-9221-947X)
- Agnieszka Pałucha-Poniewiera (ORCID: https://orcid.org/0000-0001-9890-6844)
- Anna Rafało-Ulińska (ORCID: https://orcid.org/0000-0001-7576-8039)
Institutions
- Maj Institute of Pharmacology (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1007/s00213-025-06803-0
- Citations
- 1
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Narodowe Centrum Nauki
- Narodowym Centrum Nauki
- Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk