Adolescent cardiorespiratory fitness and risk of cancer in late adulthood: A nationwide sibling-controlled cohort study in Sweden
Higher levels of adolescent cardiorespiratory fitness were associated with lower overall cancer mortality in late adulthood, a finding that persisted in sibling comparisons. However, the influence of unobserved familial confounding appeared to vary by cancer type and be more pronounced for cancer diagnoses than for mortality. This may suggest a need for robust causal methods to triangulate results, rather than relying on correlations alone, to better inform public health efforts.
Authors
- Elina Sillanpää (ORCID: https://orcid.org/0000-0001-6375-959X)
- Daniel Berglind (ORCID: https://orcid.org/0000-0003-0616-7779)
- Martin Neovius (ORCID: https://orcid.org/0000-0003-2300-3055)
- Anna Nordström (ORCID: https://orcid.org/0000-0003-3534-456X)
- Peter Nordström (ORCID: https://orcid.org/0000-0003-2924-508X)
- Francisco B. Ortega (ORCID: https://orcid.org/0000-0003-2001-1121)
- Viktor H. Ahlqvist (ORCID: https://orcid.org/0000-0003-1383-3194)
- Marcel Ballin (ORCID: https://orcid.org/0000-0002-9638-7208)
- Pontus Henriksson (ORCID: https://orcid.org/0000-0003-2482-7048)
Institutions
- Linköping University (SE)
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- Universidad de Granada (ES)
- Stockholm School of Economics (SE)
- Aarhus University (DK)
- Karolinska Institutet (SE)
- Department of Medical Sciences (RU)
- Central Finland Health Care District (FI)
- Centre for Palaeogenetics (SE)
- UiT The Arctic University of Norway (NO)
- University of Jyväskylä (FI)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1371/journal.pmed.1004597
- Primary Topic
- Childhood Cancer Survivors' Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vetenskapsrådet