A Proposal for HPV-Associated Oropharyngeal Carcinoma in the Ninth Edition Clinical TNM Classification
In this study, reclassifying each N category 1 stratum higher for iENE-positive disease resulted in better disease-free and overall survival. The proposed new classification outperformed the currently TNM staging system in risk stratification and may facilitate future clinical trial design, outcomes research, and patient care.
Authors
- Jie Su (ORCID: https://orcid.org/0000-0002-8772-8613)
- Frank Hoebers (ORCID: https://orcid.org/0000-0002-4317-9181)
- Shlomo A. Koyfman (ORCID: https://orcid.org/0000-0002-2275-5346)
- Danny Lavigne (ORCID: https://orcid.org/0000-0002-4459-9196)
- Kathryn M. Van Abel (ORCID: https://orcid.org/0000-0003-0513-4203)
- Alida A. Postma (ORCID: https://orcid.org/0000-0002-1116-054X)
- Eugene Yu (ORCID: https://orcid.org/0000-0002-6388-577X)
- Brian O’Sullivan (ORCID: https://orcid.org/0000-0001-8887-843X)
- Kristoff Nelson (ORCID: https://orcid.org/0000-0002-3506-9847)
- David M. Routman (ORCID: https://orcid.org/0000-0002-2768-003X)
- Robin L. Davis (ORCID: https://orcid.org/0000-0002-6295-7380)
- Ann Hoeben (ORCID: https://orcid.org/0000-0003-0155-3005)
- Sarah J. Stock (ORCID: https://orcid.org/0000-0003-4308-856X)
- Walter M. Palm (ORCID: https://orcid.org/0000-0002-0922-6562)
- J. Daniel (ORCID: https://orcid.org/0000-0002-2957-4687)
- Houda Bahig (ORCID: https://orcid.org/0000-0001-9508-0602)
- Laurent Létourneau‐Guillon (ORCID: https://orcid.org/0000-0002-6325-7538)
- Édith Filion
- Eric Bartlett (ORCID: https://orcid.org/0000-0001-7626-4297)
- Melvin L.K. Chua (ORCID: https://orcid.org/0000-0002-1648-1473)
- Snehal G. Patel (ORCID: https://orcid.org/0000-0001-9775-5132)
- William M. Lydiatt (ORCID: https://orcid.org/0000-0002-2394-2725)
- Anna Spreafico (ORCID: https://orcid.org/0000-0002-3034-3042)
- Neil McIver Woody (ORCID: https://orcid.org/0000-0003-4507-6167)
- Alex A. Nagelschneider
- Jonathan Lee (ORCID: https://orcid.org/0000-0001-7065-8041)
- Wei Xu (ORCID: https://orcid.org/0000-0002-0257-8856)
- Phuc Félix Nguyen‐Tan
- Shao Hui Huang
Institutions
- Creighton University (US)
- Cleveland Clinic (US)
- Mayo Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Toronto (CA)
- Maastricht University Medical Centre (NL)
- Princess Margaret Cancer Centre (CA)
- Maastricht University (NL)
- Duke-NUS Medical School (SG)
- National Cancer Centre Singapore (SG)
- Centre Hospitalier de l’Université de Montréal (CA)
- Maastro Clinic (NL)
Publication Details
- Journal
- JAMA Otolaryngology–Head & Neck Surgery
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1001/jamaoto.2025.0848
- Citations
- 11
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 20.33