The glycosaminoglycan chains of perlecan regulate the perivascular fluid transport
Potential brain clearance mechanisms are dependent on the flow through special ECM structures. BM is mainly known for its barrier function, whereas very little is known about how passage along the perivascular ECM is established. This study shows that the GAG composition of the BM affects the solute dynamics and Aβ deposition in the periarterial space.
Authors
- Lauri Eklund (ORCID: https://orcid.org/0000-0002-3177-7504)
- Mika Kaakinen (ORCID: https://orcid.org/0000-0002-1229-8196)
- Harri Elamaa (ORCID: https://orcid.org/0000-0002-0248-7890)
- Vesa J. Kiviniemi (ORCID: https://orcid.org/0000-0003-0184-8524)
- Abhishek Singh (ORCID: https://orcid.org/0000-0003-0486-5522)
Institutions
- Oulu University Hospital (FI)
- University of Oulu (FI)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s12987-025-00648-7
- Citations
- 3
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- Oulun Yliopisto