mTOR inhibition impacts the flagellin-augmented inflammatory and antimicrobial response of human airway epithelial cells to Pseudomonas aeruginosa
These results demonstrate that flagellin is a significant factor that augments the inflammatory and antimicrobial response of human airway epithelial cells upon exposure to P. aeruginosa and suggest that mTOR inhibition by rapamycin in the airway epithelium diminishes these exaggerated responses.
Authors
- Katina D. Hulme (ORCID: https://orcid.org/0000-0003-1322-0136)
- Colin A. Russell (ORCID: https://orcid.org/0000-0002-2113-162X)
- Christine C. A. van Linge (ORCID: https://orcid.org/0000-0003-2787-8895)
- Tom van der Poll (ORCID: https://orcid.org/0000-0002-9199-5079)
- Robert F. J. Kullberg (ORCID: https://orcid.org/0000-0001-8269-9887)
- Hessel Peters‐Sengers (ORCID: https://orcid.org/0000-0003-3145-864X)
- Alex F. de Vos (ORCID: https://orcid.org/0000-0002-2472-3014)
- Menno D. de Jong (ORCID: https://orcid.org/0000-0002-8380-4738)
Institutions
- Boston University (US)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1371/journal.pone.0321462
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amsterdam University Medical Centers
- European Commission
- Horizon 2020 Framework Programme
- H2020 European Research Council