Sex differences in alcohol inhibits bone formation and promotes bone resorption in young male and female rats by altering intestinal flora, metabolites, and bone microenvironment
Chronic alcohol consumption increased bone resorption, inhibited bone formation, and affected bone marrow immunoreactivity in young male and female rats. Alcohol can also affect gut microbiota composition and fecal metabolism. Female rats were more susceptible to alcohol, possibly because young female rats have a lower alcohol metabolism, immunomodulatory capacity, and gut microbiota diversity than young male rats.
Authors
- Hua Lu (ORCID: https://orcid.org/0000-0002-2709-222X)
- Tao Xiang (ORCID: https://orcid.org/0000-0002-2530-1059)
- Ming Cheng
- Yiping Wu (ORCID: https://orcid.org/0000-0002-4815-0732)
- Junwei Feng
- Long Jia
- Guanlan Zhao (ORCID: https://orcid.org/0000-0002-2354-7549)
- Lingjun Deng
Institutions
- Chengdu Sport University (CN)
- Fourth People's Hospital of Sichuan Province (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1371/journal.pone.0323222
- Citations
- 2
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.94