Bone Fragility Disorders Related to Mendelian Inheritance

Abstract: Genetics is a discipline of study that can be traced back to Gregor Johann Mendel, making it unique among other fields. Mendel's investigations led to the discovery of three inheritance rules, now known as Mendel's rules of inheritance or Mendelism. The bone is unique among structural materials in that it can self-repair and modify its properties and configuration in reaction to changes. It also contains four types of cells: osteoblasts, bone lining cells, osteocytes, and osteoclasts. This study examines bone fragility illnesses linked to Mendelian inheritance. We briefly cover illnesses such as osteoporosis, osteopetrosis, osteogenesis imperfecta, and current results. Investigating Mendelian laws led to a better understanding of inherited bone fragility syndromes. Bone fragility is a pathological condition characterized by changed mineralized bone mass and degradation of bone tissue, leading to reduced bone strength and increased fracture risk, even without high-impact trauma. Primary osteoporosis is the leading cause of bone fragility in the older population. Bone fragility can occur at any age due to congenital uncommon bone metabolic illnesses caused by inherited genetic defects that disrupt proper bone structure.