Transcriptome-wide analysis reveals potential roles of CFD and ANGPTL4 in fibroblasts regulating B cell lineage for extracellular matrix-driven clustering and novel avenues for immunotherapy in breast cancer
We identified distinct ECM clusters in breast cancer patients, irrespective of molecular subtypes. Additionally, we constructed an effective prognostic model based on these ECM clusters and recognized ANGPTL4<sup>+</sup> and CFD<sup>+</sup> fibroblasts as potential biomarkers for immunotherapy in breast cancer.
Authors
- Mei Lan (ORCID: https://orcid.org/0000-0002-3408-0577)
- Yingpu Li (ORCID: https://orcid.org/0000-0002-3708-7926)
- Rong Huang (ORCID: https://orcid.org/0000-0002-1118-3450)
- Hongwei Wang (ORCID: https://orcid.org/0000-0003-2868-5112)
- Kexin Liu (ORCID: https://orcid.org/0000-0002-0699-8452)
- Yiping Zhu (ORCID: https://orcid.org/0000-0003-0946-8972)
- Sifan Zhang (ORCID: https://orcid.org/0000-0002-6086-9678)
- Zhigao Li
Institutions
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s10020-025-01237-y
- Citations
- 5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 7.59