The effect of lidocaine against sepsis-induced acute lung injury in a mouse model through the JAK2/STAT3 pathway
Intravenous lidocaine effectively alleviated acute lung injury in septic mice. The anti-inflammatory effects of lidocaine may be attributed to its suppression of the JAK2/STAT3 signaling pathway and its anti-apoptotic effects.
Authors
- Qian Chen (ORCID: https://orcid.org/0000-0002-0130-5901)
- Lunmeng Cui (ORCID: https://orcid.org/0000-0002-8700-4084)
- Fengsong Xie
- Ying Cai (ORCID: https://orcid.org/0000-0001-6550-1373)
- Hong Zhang (ORCID: https://orcid.org/0000-0002-4766-4221)
Institutions
- Mudanjiang Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1371/journal.pone.0322653
- Citations
- 1
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.80