Neurological outcomes and disability predictors in paediatric herpes simplex virus encephalitis: a multicentre cohort from French tertiary hospitals
Our findings indicate that despite decrease in mortality rates, neurological disabilities in children with HSVE still persist at high levels. This underscores the need to enhance HSVE management strategies. Moreover, the identified risk factors associated with poor neurological outcomes can aid in identifying high-risk children, facilitating the implementation of alternative treatment approaches such as immunotherapy or intensive rehabilitation.
Authors
- Sylvain Renolleau (ORCID: https://orcid.org/0000-0002-0638-5613)
- Hélène Maurey
- Anne Rolland (ORCID: https://orcid.org/0000-0002-1225-2964)
- Anne‐Lise Poulat (ORCID: https://orcid.org/0000-0002-5914-2498)
- Frédéric Villega (ORCID: https://orcid.org/0000-0002-5423-3171)
- Pierre Castelnau (ORCID: https://orcid.org/0000-0002-4152-9731)
- Kumaran Deiva (ORCID: https://orcid.org/0000-0002-8409-2365)
- Pierre Meyer (ORCID: https://orcid.org/0000-0001-5710-7376)
- Emmanuel Cheuret (ORCID: https://orcid.org/0000-0002-2105-2518)
- Sarah Baer (ORCID: https://orcid.org/0000-0003-4951-2552)
- Stéphane Auvin (ORCID: https://orcid.org/0000-0003-3874-9749)
- Laetitia Giorgi
- Daniel Amsallem
- Juliette Ropars (ORCID: https://orcid.org/0000-0001-7467-759X)
- J.-M. Pinard
- Sylvie Nguyen The Tich
- Caroline Rey
- Pierre-Louis Léger
- Anne Lépine (ORCID: https://orcid.org/0000-0002-9844-9687)
- Diana Rodriguez
- Renaldo Florence
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Lille (FR)
- Université Paris-Saclay (FR)
- Sorbonne Université (FR)
- Hôpital Armand-Trousseau (FR)
- Assistance Publique Hôpitaux de Marseille (FR)
- Centre Hospitalier Universitaire de Besançon (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de Référence des Maladies Autoinflammatoires et des Amyloses (FR)
- Hospices Civils de Lyon (FR)
- Institut Interdisciplinaire de Neuroscience (FR)
- Hôpital Raymond-Poincaré (FR)
- Institute for Neurosciences of Montpellier (FR)
- Hôpital Purpan (FR)
- Hôpitaux Universitaires de Strasbourg (FR)
- Laboratoire de Traitement de l'Information Médicale (FR)
- Bicêtre Hospital (FR)
- HCL Technologies (India) (IN)
- Nantes Université (FR)
Publication Details
- Journal
- European Journal of Paediatric Neurology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1016/j.ejpn.2025.05.001
- Citations
- 3
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.06