Pervasive glycative stress links metabolic imbalance and muscle atrophy in early-onset Parkinson's disease
Our results offer the first proof for a direct link between diet, accumulation of AGEs and genetics of PD. We also expand the repertoire of clinically-relevant glycative stress biomarkers to potentially define at-risk patients before neurological or metabolic symptoms arise, and/or to monitor disease onset, progression, and effects of interventions.
Authors
- Natália Prudente de Mello (ORCID: https://orcid.org/0000-0002-2343-7884)
- Margarita Chudenkova
- Agnita J.W. Boon (ORCID: https://orcid.org/0000-0002-5042-2792)
- Wim Mandemakers (ORCID: https://orcid.org/0000-0003-2673-5972)
- Giovanni Cossu (ORCID: https://orcid.org/0000-0002-9129-2584)
- Leopold Weidner (ORCID: https://orcid.org/0000-0002-6801-3647)
- Kim A. Lagerborg (ORCID: https://orcid.org/0000-0003-2490-2191)
- Wolfgang Wurst (ORCID: https://orcid.org/0000-0003-4422-7410)
- Stefano Ciciliot (ORCID: https://orcid.org/0000-0002-5833-6581)
- Yingfei Yan
- Philippe Schmitt‐Kopplin (ORCID: https://orcid.org/0000-0003-0824-2664)
- Susanne Keipert (ORCID: https://orcid.org/0000-0002-6618-7379)
- Mohit Raja Jain (ORCID: https://orcid.org/0000-0002-1789-7235)
- Jennifer Wettmarshausen
- Fabiana Perocchi (ORCID: https://orcid.org/0000-0002-1102-6500)
- Gabriele Möller (ORCID: https://orcid.org/0000-0002-2730-1351)
- Vincenzo Bonifati (ORCID: https://orcid.org/0000-0002-9334-1263)
- Martin Jastroch (ORCID: https://orcid.org/0000-0003-0358-3865)
- Janina Tokarz (ORCID: https://orcid.org/0000-0003-4344-4149)
- Anneke J.A. Kievit (ORCID: https://orcid.org/0000-0001-8931-4062)
- Jerzy Adamski (ORCID: https://orcid.org/0000-0001-9259-0199)
- Kenneth A. Dyar (ORCID: https://orcid.org/0000-0002-9010-8757)
- Safal Walia
- Daniela M. Vogt Weisenhorn (ORCID: https://orcid.org/0000-0002-4566-6506)
- Michael Berger (ORCID: https://orcid.org/0000-0002-7239-1675)
- Roland Nilsson (ORCID: https://orcid.org/0000-0002-6020-7498)
- Yan Cheng (ORCID: https://orcid.org/0000-0003-2043-4335)
- Anna Artati
Institutions
- Karolinska University Hospital (SE)
- Stockholm University (SE)
- National University of Singapore (SG)
- Erasmus MC (NL)
- Karolinska Institutet (SE)
- Helmholtz Zentrum München (DE)
- University of California San Diego (US)
- Veneto Institute of Molecular Medicine (IT)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Azienda Ospedaliera G. Brotzu (IT)
- Heinrich Heine University Düsseldorf (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1016/j.molmet.2025.102163
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78