Sex Differences in Diabetic Cardiomyopathy and Treatment Response to AT-001
Despite baseline differences between women and men with DbCM, the efficacy and safety of high-dose AT-001 are comparable across sexes. These findings highlight the presence of sex-specific characteristics in DbCM and underscore the importance of further research to understand potential sex-specific mechanisms. (Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure Trial [ARISE-HF]; NCT04083339).
Authors
- Justin Adrian Ezekowitz (ORCID: https://orcid.org/0000-0002-2724-4086)
- Riccardo Perfetti (ORCID: https://orcid.org/0000-0003-1643-0585)
- Alessia Urbinati (ORCID: https://orcid.org/0000-0001-9824-2398)
- Stefano Del Prato (ORCID: https://orcid.org/0000-0002-5388-0270)
- Gregory D. Lewis (ORCID: https://orcid.org/0000-0001-8108-8240)
- W.H. Wilson Tang (ORCID: https://orcid.org/0000-0002-8335-735X)
- Faiez M. Zannad (ORCID: https://orcid.org/0000-0001-7456-1570)
- James Louis Januzzi (ORCID: https://orcid.org/0000-0002-8338-1798)
- Julio Rosenstock (ORCID: https://orcid.org/0000-0001-8324-3275)
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Carolyn S.P. Lam (ORCID: https://orcid.org/0000-0003-1903-0018)
- Nasrien E. Ibrahim (ORCID: https://orcid.org/0000-0003-3376-5336)
- Javed Butler (ORCID: https://orcid.org/0000-0003-4267-6933)
- Vanessa Blumer (ORCID: https://orcid.org/0000-0001-5062-5015)
- Yuxi Liu (ORCID: https://orcid.org/0009-0002-2876-8567)
- Sheila Hedge
Institutions
- Brigham and Women's Hospital (US)
- Cleveland Clinic (US)
- Harvard University (US)
- University of Alberta (CA)
- Inserm (FR)
- Scuola Superiore Sant'Anna (IT)
- University of Mississippi Medical Center (US)
- National University Heart Centre Singapore (SG)
- Baim Institute for Clinical Research (US)
- Velocity Clinical Research (United States) (US)
- Université de Lorraine (FR)
Publication Details
- Journal
- JACC Heart Failure
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1016/j.jchf.2025.02.015
- Citations
- 3
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 4.16