Enhancement of spinosad production in Saccharopolyspora spinosa by overexpression of the complete 74-kb spinosyn gene cluster
This study is the first to successfully overexpress the complete spn gene cluster in Sa. spinosa, significantly enhancing spinosad production. These findings have significance for further optimization of spinosad biosynthesis.
Authors
- Shaoxin Chen (ORCID: https://orcid.org/0000-0002-1604-816X)
- Jingtao Chen (ORCID: https://orcid.org/0000-0002-4720-4225)
- Zhichun Shen
- Jiyang Li
- Zhengyu Zhang (ORCID: https://orcid.org/0000-0002-5692-5665)
- Lu Gan (ORCID: https://orcid.org/0000-0001-5726-1496)
- W. Q. Chen
Institutions
- Fudan University (CN)
- Shanghai Institute of Pharmaceutical Industry (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s12934-025-02724-x
- Citations
- 2
- Primary Topic
- Plant Disease Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 3.50
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- National Key Research and Development Program of China