Evaluation of Ficolin-3 deficiency as a risk factor in the development of rheumatic heart disease
Ficolin-3 was found to be increased by 16% in RHD patients (p = 0.03) compared to controls, but polymorphisms did not associate with the risk of developing RHD nor with ficolin-3 concentrations. Carriers of the c.349del haploinsufficiency locus had normal levels of ficolin-3, while the previously described c.658 + 250 C > A RHD susceptibility locus was found equally in cases and controls. The higher serum ficolin-3 in RHD supports the potential role of this protein in RHD pathogenesis. However, these results suggest that rs532781899 and rs4494157 are not risk factors for the development of RHD in patients from sub-Saharan Africa and would not be reliable as early-stage markers of RHD susceptibility.
Authors
- Timothy F. Spracklen (ORCID: https://orcid.org/0000-0002-7919-6848)
- Mark E. Engel (ORCID: https://orcid.org/0000-0002-1334-8829)
- Zahra Parker
- Liesl Zühlke (ORCID: https://orcid.org/0000-0003-3961-2760)
- Muneeb Salie (ORCID: https://orcid.org/0000-0002-7980-0048)
- Kélin Engel
Institutions
- South African Medical Research Council (ZA)
- University of Cape Town (ZA)
Publication Details
- Journal
- BMC Research Notes
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s13104-025-07251-x
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department for International Development, UK Government
- National Research Foundation
- South African Medical Research Council
- Medical Research Council