Global consensus from the PHITT consortium surrounding an interim chemotherapy guidance for the treatment of children with hepatoblastoma, hepatocellular neoplasm – not otherwise specified (HCN-NOS), hepatocellular carcinoma and fibrolamellar carcino
<h2>Abstract</h2> Malignant liver tumors affecting children and adolescents are rare. In order to adequately study liver tumors occurring in this patient population and establish a more uniform approach to therapy, the three primary liver tumor consortia, SIOPEL (mainly European), COG (mainly North American) and JCCG (Japan), in concert, designed an international prospective clinical trial [PHITT (Paediatric Hepatic International Tumour Trial)/COGAHEP1531/JPLT4 – to be referred to as PHITT from this point forth] for the study of hepatoblastoma and hepatocellular carcinoma in children and adolescents. Recruitment to PHITT has recently concluded. The major results from this trial will be published in the next 2-3 years, therefore in the interim, we sought to provide a consensus statement on evidence-based chemotherapy guidance for hepatoblastoma and hepatocellular carcinoma of all stages.
Authors
- Isabelle Aerts (ORCID: https://orcid.org/0000-0002-5213-3353)
- Tomoro Hishiki (ORCID: https://orcid.org/0000-0002-2515-1054)
- Milind Ronghe (ORCID: https://orcid.org/0000-0002-1865-9335)
- Brice Fresneau (ORCID: https://orcid.org/0000-0001-7603-7828)
- Kenichiro Watanabe (ORCID: https://orcid.org/0000-0002-8892-3082)
- Eiso Hiyama (ORCID: https://orcid.org/0000-0001-9179-5037)
- Penelope Brock (ORCID: https://orcid.org/0000-0003-1239-6316)
- Kathelijne C.J.M. Kraal (ORCID: https://orcid.org/0000-0001-9630-0814)
- Jim Geller
- Marcio H. Malogolowkin
- Danielle Ingham
- Angela D. Trobaugh‐Lotrario (ORCID: https://orcid.org/0000-0002-2668-7686)
- Greg Tiao (ORCID: https://orcid.org/0000-0001-8099-2596)
- Michael Sullivan (ORCID: https://orcid.org/0000-0002-8606-5889)
- Allison F. O’Neill (ORCID: https://orcid.org/0000-0002-8957-3870)
- Arun Rangaswami
- Madhumita Dandapani (ORCID: https://orcid.org/0000-0001-8444-6007)
- Marc Ansari (ORCID: https://orcid.org/0000-0002-9649-6498)
- József Zsíros
- Irene Schmid (ORCID: https://orcid.org/0000-0002-5105-3597)
- Sophie Branchereau
Institutions
- University of Geneva (CH)
- Providence Sacred Heart Medical Center (US)
- Cincinnati Children's Hospital Medical Center (US)
- Royal Children's Hospital (AU)
- Nottingham University Hospitals NHS Trust (GB)
- University of California, San Francisco (US)
- Université Paris Sciences et Lettres (FR)
- Université Paris-Saclay (FR)
- Leeds Teaching Hospitals NHS Trust (GB)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- Royal Hospital for Children (GB)
- Institut Gustave Roussy (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Chiba University Hospital (JP)
- University Hospital of Geneva (CH)
- Hiroshima University Hospital (JP)
- University Children's Hospital Tübingen (DE)
- Princess Máxima Center (NL)
- University of California Davis Medical Center (US)
- Shizuoka Children's Hospital (JP)
- Bicêtre Hospital (FR)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- University of Cincinnati (US)
- Institut Curie (FR)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- EJC Paediatric Oncology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1016/j.ejcped.2025.100235
- Citations
- 4
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 5.29