Endothelial cell dysfunction in RA: biomarkers IL-8, E-selectin, VCAM-1 and MCP-1 correlated with PET/CT
Anti-inflammatory therapy in RA gives early and sustained reductions in endothelial biomarkers, particularly E-selectin and IL-8, with significant differences across subgroups defined by disease activity and therapeutic responses, and provide significant correlations with aortic regions by FDG PET/CT. These findings highlight a potential therapeutic benefit in reducing cardiovascular risk in patients with RA.
Authors
- A. Blanken (ORCID: https://orcid.org/0000-0002-9728-5510)
- Michael Twahier Nurmohamed (ORCID: https://orcid.org/0000-0002-6274-1934)
- Bas Dijkshoorn (ORCID: https://orcid.org/0009-0001-1698-5647)
- Geoffrey W. de Mooij
- Călin D. Popa (ORCID: https://orcid.org/0000-0001-9470-9720)
Institutions
- Radboud University Nijmegen (NL)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Reade (NL)
- Amsterdam Neuroscience (NL)
- University Hospital and Clinics (US)
- Radboud Institute for Molecular Life Sciences (NL)
- Sint Maartenskliniek (NL)
- Amsterdam University Medical Centers (NL)
- Center for Rheumatology (US)
- University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1093/rheumatology/keaf208
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00