Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries
Combining transdiagnostic and disorder-level genetic approaches can improve our understanding of co-occurring conditions and increase the specificity of genetic discovery, which is critical for identifying more effective prevention and treatment strategies to reduce the burden of these disorders.
Authors
- Alexander S. Hatoum (ORCID: https://orcid.org/0000-0002-8002-7267)
- Emily E. Hartwell (ORCID: https://orcid.org/0000-0002-5137-9714)
- Roseann E. Peterson (ORCID: https://orcid.org/0000-0001-6402-849X)
- Yousef Khan (ORCID: https://orcid.org/0009-0002-3093-3947)
- Sandra Sanchez‐Roige (ORCID: https://orcid.org/0000-0001-6137-5699)
- Christal N. Davis (ORCID: https://orcid.org/0000-0003-3974-5598)
- Rachel L. Kember (ORCID: https://orcid.org/0000-0001-8820-2659)
- Sylvanus Toikumo (ORCID: https://orcid.org/0000-0002-6024-0693)
- Kyra Feuer (ORCID: https://orcid.org/0000-0003-3704-6136)
- Zeal Jinwala (ORCID: https://orcid.org/0009-0005-5062-0827)
- Henry R. Kranzler
Institutions
- SUNY Downstate Health Sciences University (US)
- Washington University in St. Louis (US)
- University of California San Diego (US)
- Philadelphia VA Medical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1016/j.biopsych.2025.04.021
- Citations
- 5
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 7.27