Absolute quantification of donor-derived cell-free DNA following pediatric and adult heart transplantation
dd-cfDNA found good discrimination between cardiac recipients with and without rejection. Absolute quantification of dd-cfDNA with ddPCR is a fast and effective method to monitor graft health. Analyzing absolute dd-cfDNA levels helps identify other factors, besides rejection, that may influence cfDNA levels, potentially reducing the need for EMB.
Authors
- Göran Dellgren (ORCID: https://orcid.org/0000-0003-4961-9704)
- Håkan Wåhlander (ORCID: https://orcid.org/0000-0002-4753-3811)
- Staffan Nilsson (ORCID: https://orcid.org/0000-0003-4748-0446)
- Karin Tran‐Lundmark (ORCID: https://orcid.org/0000-0001-5973-2618)
- Michal Odermarsky (ORCID: https://orcid.org/0000-0002-0852-5691)
- Jens Böhmer (ORCID: https://orcid.org/0000-0001-6801-8352)
- Kristjan Karason (ORCID: https://orcid.org/0000-0002-2802-1191)
- Anne Ricksten
- Julia Asp (ORCID: https://orcid.org/0000-0001-9648-8407)
- Stephen Jan (ORCID: https://orcid.org/0000-0003-2839-1405)
- Maria Sjöborg Alpman (ORCID: https://orcid.org/0000-0002-2622-5975)
Institutions
- Karolinska University Hospital (SE)
- Lund University (SE)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- Skåne University Hospital (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- The Journal of Heart and Lung Transplantation
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1016/j.healun.2025.04.024
- Citations
- 4
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- VINNOVA
- Sahlgrenska Universitetssjukhuset