Systematic review and independent validation of genetic factors of radiographic outcome in rheumatoid arthritis identifies a genome-wide association with CARD9
We provide a comprehensive list of validated genetic associations with RA outcome and demonstrate that non-HLA polymorphisms can associate with radiographic severity independently of disease susceptibility. This highlights the importance of dedicated genetic outcome studies for patient stratification in precision medicine for RA.
Authors
- Nisha Nair (ORCID: https://orcid.org/0000-0001-9829-792X)
- H.W. van Steenbergen (ORCID: https://orcid.org/0000-0002-3251-0238)
- Max M. Yates (ORCID: https://orcid.org/0000-0003-3977-8920)
- John Bowes (ORCID: https://orcid.org/0000-0003-4659-031X)
- Ryan Malcolm Hum (ORCID: https://orcid.org/0000-0003-0801-6974)
- Rachel Knevel (ORCID: https://orcid.org/0000-0002-7494-3023)
- Suzanne M. M. Verstappen (ORCID: https://orcid.org/0000-0001-6181-0646)
- Anne C Barton (ORCID: https://orcid.org/0000-0003-3316-2527)
- Lysette Marshall (ORCID: https://orcid.org/0000-0002-9386-1234)
- Alex J. MacGregor (ORCID: https://orcid.org/0000-0003-2163-2325)
- Annette H M van der Helm–van Mil (ORCID: https://orcid.org/0000-0001-8572-1437)
- Alice Storrie
- Sébastien Viatte (ORCID: https://orcid.org/0000-0001-6471-3358)
- Andrew P. Morris
- Seema Sharma (ORCID: https://orcid.org/0000-0002-9030-0482)
Institutions
- Norfolk and Norwich University Hospital (GB)
- Leiden University Medical Center (NL)
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
- Arthritis UK (GB)
- NIHR Manchester Biomedical Research Centre (GB)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1016/j.ard.2025.04.007
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- European Commission
- ZonMw
- Manchester Biomedical Research Centre
- HORIZON EUROPE Framework Programme
- Medical Research Council