Causal relationship and mediating role between depression and cognitive performance
A two-way causal relationship between depression and cognitive performance, with pain and frailty being mediating factors, respectively. Future research should prioritize mechanistic studies, targeted interventions, and personalized approaches to disentangle and mitigate the bidirectional effects of depression and cognitive performance.
Authors
- Xinyu Hao (ORCID: https://orcid.org/0000-0002-1764-0499)
- Yanhong Liu (ORCID: https://orcid.org/0000-0002-7349-5871)
- Jingsheng Lou (ORCID: https://orcid.org/0000-0002-0295-5105)
- Ziyao Xu
- Tianyue Mi (ORCID: https://orcid.org/0000-0002-9936-3017)
- Yongxin Guo
- Weidong Mi (ORCID: https://orcid.org/0000-0002-2404-0555)
- Zhuoning Zhang (ORCID: https://orcid.org/0009-0004-9513-5019)
- Tong Li (ORCID: https://orcid.org/0000-0002-8881-0037)
- Lei Wang (ORCID: https://orcid.org/0000-0002-0961-0441)
- Fuyang Cao (ORCID: https://orcid.org/0000-0002-3746-8489)
- Zhikang Zhou (ORCID: https://orcid.org/0000-0003-1280-1852)
- Xianyang Chen (ORCID: https://orcid.org/0000-0003-0405-9029)
- Jiangbei Cao (ORCID: https://orcid.org/0000-0003-1218-4639)
- Shaohua You
Institutions
- University of South Carolina (US)
- Chinese PLA General Hospital (CN)
- Beijing Institute of Big Data Research (CN)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100196
- Citations
- 4
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 4.90