Deciphering the molecular mechanisms of QLQX capsules in heart failure: A multi-omics perspective
QLQX exerts multifaceted therapeutic effects on HFpEF by modulating gene expression, protein function, and metabolic pathways, particularly through the cGMP-PKG signaling pathway. These findings support QLQX as a promising therapeutic intervention for HFpEF, offering improvements in cardiac function and reversing pathological changes at multiple molecular levels.
Authors
- Yuanyuan Hao (ORCID: https://orcid.org/0000-0002-4990-4380)
- Jiameng Hao
- Tao Song (ORCID: https://orcid.org/0000-0001-6150-0429)
- Zhenhua Jia (ORCID: https://orcid.org/0000-0002-5154-4839)
- Yunlong Hou (ORCID: https://orcid.org/0000-0002-6989-8221)
- Mingye Wang (ORCID: https://orcid.org/0000-0001-9507-4181)
- Qiulan Wu
- Liping Chang (ORCID: https://orcid.org/0000-0002-8895-3337)
Institutions
- Hebei Medical University (CN)
- Hebei Yiling Hospital (CN)
- Hebei University of Chinese Medicine (CN)
- Shijiazhuang Yiling Pharmaceutical (China) (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1016/j.phymed.2025.156828
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00