Association between blood pressure traits, hypertension, antihypertensive drugs and calcific aortic valve stenosis: a mendelian randomization study
Hypertension has a causal relationship with CAVS. Managing SBP in hypertensive patients with CCBs may prevent CAVS. ARBs might exert protective effects on CAVS independent of blood pressure reduction. The relationship between diuretics and CAVS is complex, with opposite effects through different mechanisms.
Authors
- F Huang
- Y. Zhang (ORCID: https://orcid.org/0000-0001-8810-5891)
- Yanjiani Xu
- Yan Wang (ORCID: https://orcid.org/0000-0001-5624-6745)
- Jing Wen Zhou (ORCID: https://orcid.org/0000-0001-8336-7278)
- Jialiang Zhang (ORCID: https://orcid.org/0000-0003-4704-0539)
- Mao Chen (ORCID: https://orcid.org/0009-0006-6677-9848)
- Weifu Lei
- Fei Xu (ORCID: https://orcid.org/0000-0003-0569-661X)
- Yun Liao (ORCID: https://orcid.org/0000-0001-6603-7437)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Journal of Geriatric Cardiology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.26599/1671-5411.2025.03.008
- Citations
- 1
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China
- Sichuan University
- Medical Research Council
- West China Hospital, Sichuan University