Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination
We used epidemiological data from 21195 patients with cancer and 180407 matched controls, including in-depth analyses in 216 cancer patients, to discover clinical and molecular determinants that predispose cancer patients to breakthrough infections. Patients with B cell malignancies, with differential expression of CD24, CDK14 and PLEKHG1, were most susceptible to breakthrough infections, suggesting that these patients may require more booster immunisations to ameliorate cellular responses and immune protection against COVID-19.
Authors
- Rahul Pandey (ORCID: https://orcid.org/0000-0001-7766-3572)
- Shaun Shi Yan Tan (ORCID: https://orcid.org/0000-0003-4100-0165)
- Shi Yin Wong
- Kuan Rong Chan (ORCID: https://orcid.org/0000-0002-2427-671X)
- Chee Wah Tan (ORCID: https://orcid.org/0000-0001-9837-1413)
- Barnaby Edward Young (ORCID: https://orcid.org/0000-0003-1010-2230)
- Chun En Yau (ORCID: https://orcid.org/0000-0002-5844-8962)
- Joline S.J. Lim (ORCID: https://orcid.org/0000-0001-8979-8597)
- Perumal Dharuman
- Sidney Yee
- Eillyne Seow (ORCID: https://orcid.org/0009-0003-6022-6909)
- Soo Chin Lee (ORCID: https://orcid.org/0000-0002-5835-6419)
- Louis Yi Ann Chai (ORCID: https://orcid.org/0000-0002-9640-0791)
- Alexander Lezhava
- Clara WT Koh (ORCID: https://orcid.org/0000-0003-1413-6032)
- Chen Ee Low (ORCID: https://orcid.org/0000-0002-8652-0984)
- Ruifen Weng
- Raghav Sundar (ORCID: https://orcid.org/0000-0001-9423-1368)
- Carina Jing Xuan Tay
- Arun George Devasia
- Youjia Zhong (ORCID: https://orcid.org/0000-0002-3795-6319)
- Esther Hian Li Chan (ORCID: https://orcid.org/0000-0003-1006-5601)
- Matilda Lee (ORCID: https://orcid.org/0000-0001-9924-4547)
- Wee Chee Yap (ORCID: https://orcid.org/0000-0001-8470-5806)
- Ainsley Ryan Yan Bin Lee (ORCID: https://orcid.org/0000-0002-5896-2929)
- Kelvin Bryan Tan (ORCID: https://orcid.org/0000-0002-4778-7184)
- Carol LF Ho
- Jiaqi Li (ORCID: https://orcid.org/0000-0002-1201-7489)
- Su Yan (ORCID: https://orcid.org/0000-0003-0001-8692)
- Janice Yu Jin Tan
- Candy Khoo
- Panneer Selvi Govindaraju
Institutions
- Agency for Science, Technology and Research (SG)
- Ministry of Health (SG)
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- Tan Tock Seng Hospital (SG)
- National University Cancer Institute, Singapore (SG)
- Duke-NUS Medical School (SG)
- National University Hospital (SG)
- National University Health System (SG)
- National Centre for Infectious Diseases (SG)
- Genome Institute of Singapore (SG)
- Stanford University (US)
Publication Details
- Journal
- npj Vaccines
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1038/s41541-025-01141-w
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National University of Singapore
- National University Cancer Institute, Singapore
- Temasek Foundation
- Medical Research Council
- National Medical Research Council