Gut microbiota mediates SREBP-1c-driven hepatic lipogenesis and steatosis in response to zero-fat high-sucrose diet
Sucrose-microbiota interactions and SREBP-1c are required for DNL and hepatic steatosis in the absence of dietary fat. These findings provide new insights into the complex interplay between diet, gut microbiota, and metabolic regulation.
Authors
- Marcus Henricsson (ORCID: https://orcid.org/0000-0002-4202-0339)
- Michaël Kahn (ORCID: https://orcid.org/0000-0003-1220-4644)
- Lisa Olsson (ORCID: https://orcid.org/0000-0001-9730-1915)
- Mattias Bergentall
- Adil Mardinoğlu (ORCID: https://orcid.org/0000-0002-4254-6090)
- Louise Mannerås Holm
- Max Nieuwdorp (ORCID: https://orcid.org/0000-0002-1926-7659)
- Fredrik Bäckhed (ORCID: https://orcid.org/0000-0002-4871-8818)
- Chuqing Sun (ORCID: https://orcid.org/0000-0001-5025-2650)
- Valentina Tremaroli (ORCID: https://orcid.org/0000-0002-9150-4233)
- Per‐Olof Bergh (ORCID: https://orcid.org/0000-0001-9993-6965)
- Robert Caesar (ORCID: https://orcid.org/0000-0003-1017-2933)
- Antonio Molinaro (ORCID: https://orcid.org/0000-0003-3432-2238)
Institutions
- Sahlgrenska University Hospital (SE)
- Amsterdam University Medical Centers (NL)
- KTH Royal Institute of Technology (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1016/j.molmet.2025.102162
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Västra Götalandsregionen
- Torsten Söderbergs Stiftelse
- Göran Gustafssons Stiftelser
- Stiftelsen för Strategisk Forskning
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Hjärt-Lungfonden
- Knut och Alice Wallenbergs Stiftelse
- Novo Nordisk
- Vetenskapsrådet
- Sahlgrenska Universitetssjukhuset
- Diabetesfonden
- Science for Life Laboratory
- Novo Nordisk Fonden
- European Research Council