Abundance of a metabolically active subpopulation in dedifferentiated adipocytes inversely correlates with body mass index
Our results not only characterize DFAT cells derived from human adipose tissue, but also identify a specific subpopulation with increased energy expenditure that may play a role in body weight control. Future efforts to identify possible therapeutic targets or to promote the enrichment or activation of these energy-burning cells in adipose tissue might be useful in the field of cardiometabolic diseases.
Authors
- Daniel D. Lam (ORCID: https://orcid.org/0000-0001-8593-3157)
- Adhideb Ghosh (ORCID: https://orcid.org/0000-0002-5160-4571)
- Anne Hoffmann (ORCID: https://orcid.org/0000-0003-3258-3397)
- Christian Wolfrum (ORCID: https://orcid.org/0000-0002-3862-6805)
- Lucas Massier (ORCID: https://orcid.org/0000-0002-6199-2643)
- Falko Noé (ORCID: https://orcid.org/0009-0002-3360-5455)
- Miriam Wittmann (ORCID: https://orcid.org/0000-0003-2328-4926)
- Heike Neubauer (ORCID: https://orcid.org/0000-0001-8470-968X)
- Matthias Blüher (ORCID: https://orcid.org/0000-0003-0208-2065)
- Jonathan Trujillo Viera (ORCID: https://orcid.org/0000-0003-0566-4589)
- Jiawei Zhong
- Yang Shen (ORCID: https://orcid.org/0000-0001-6607-7818)
- Holger Klein (ORCID: https://orcid.org/0000-0002-6904-2319)
- Alec Dick
- Bradford S. Hamilton
- Coralie Viollet
Institutions
- Boehringer Ingelheim (Germany) (DE)
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Helmholtz Zentrum München (DE)
- ETH Zurich (CH)
- University Hospital Leipzig (DE)
- Boehringer Ingelheim (Australia) (AU)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1016/j.molmet.2025.102161
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00