Effect of contraceptive methods on the vaginal microbiome and host immune factors
Our findings suggest that copper IUDs are associated with decreased prevalence of Lactobacillus-dominated microbiomes, higher transition rates towards less optimal microbiome and increased inflammatory profiles, which may lead to negative implications for gynecologic and reproductive health, the LNG-implant may offer positive health benefits with increased prevalence of L. crispatus-dominated microbiomes.
Authors
- Charles Morrison (ORCID: https://orcid.org/0000-0002-9873-3194)
- Katherine M. Spaine
- Anna‐Lise Williamson (ORCID: https://orcid.org/0000-0002-5467-1200)
- Bahiah Meyer (ORCID: https://orcid.org/0000-0003-0641-3546)
- Bin Zhu (ORCID: https://orcid.org/0000-0003-2829-2925)
- Lindi Masson (ORCID: https://orcid.org/0000-0002-2539-817X)
- Laahirie Edupuganti
- Kavita Nanda (ORCID: https://orcid.org/0000-0001-7650-2929)
- Nina Radzey
- Myrna G. Serrano (ORCID: https://orcid.org/0000-0003-4327-0193)
- Kimberly K. Jefferson (ORCID: https://orcid.org/0000-0003-1052-1988)
- Florence Lefebvre d’Hellencourt (ORCID: https://orcid.org/0009-0007-3794-4864)
- Mags E. Beksinska (ORCID: https://orcid.org/0000-0002-4169-4112)
- Celia Mehou‐Loko
- Gregory A. Buck (ORCID: https://orcid.org/0000-0003-4621-3987)
- Khatija Ahmed (ORCID: https://orcid.org/0000-0003-0309-1641)
- David Edwards (ORCID: https://orcid.org/0000-0003-2964-8620)
- Jennifer Deese (ORCID: https://orcid.org/0000-0003-1535-1076)
- Ongeziwe Taku (ORCID: https://orcid.org/0000-0003-4402-4891)
- Rushil Harryparsad
- Veronique Bailey (ORCID: https://orcid.org/0000-0002-3626-285X)
- Jerome F. Strauss (ORCID: https://orcid.org/0000-0001-6199-0480)
- Jennifer Smit (ORCID: https://orcid.org/0000-0002-5337-5995)
Institutions
- Family Health International 360 (US)
- Yahoo (United Kingdom) (GB)
- Tshwane University of Technology (ZA)
- University of Cape Town (ZA)
- Virginia Commonwealth University (US)
- University of the Witwatersrand (ZA)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Wellcome Centre for Infectious Diseases Research in Africa (ZA)
- Setshaba Research Centre (ZA)
- University of Pretoria (ZA)
Publication Details
- Journal
- Contraception
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1016/j.contraception.2025.110936
- Citations
- 3
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 3.55