High Levels of Plasma and Plaque IsoDGR-Modified Fibronectin are Associated with Rupture Prone Plaque Characteristics in Carotid Endarterectomy Patients
In this large human cohort study, high plasma and plaque levels of isoDGR fibronectin were associated with more plaque macrophages and other adverse plaque characteristics. This suggests the involvement of isoDGR fibronectin in human plaque destabilisation and blocking isoDGR modifications as a potential treatment modality.
Authors
- Joost Hoekstra (ORCID: https://orcid.org/0000-0002-2473-5963)
- Gert J. de Borst (ORCID: https://orcid.org/0000-0002-1389-4141)
- Tetiana Motsak (ORCID: https://orcid.org/0000-0002-5545-8583)
- Gerard Pasterkamp (ORCID: https://orcid.org/0000-0001-5345-1022)
- SoFong Cam Ngan (ORCID: https://orcid.org/0000-0002-1833-2746)
- Barend M. Mol (ORCID: https://orcid.org/0009-0009-3714-5514)
- Siu Kwan Sze (ORCID: https://orcid.org/0000-0002-5652-1687)
- Valentina Osorio Zuluaga
- Saskia Rumpff-Derksen
- Ioanna Paspali-Strik
- Dominique P V de Kleijn
Institutions
- Brock University (CA)
- University Medical Center Utrecht (NL)
- Central Military Hospital (NL)
- Bogomolets National Medical University (UA)
Publication Details
- Journal
- European Journal of Vascular and Endovascular Surgery
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1016/j.ejvs.2025.04.067
- Citations
- 5
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 7.59