Sex-specific genetic effects on susceptibility to idiopathic pulmonary fibrosis
The predictive accuracy of common autosomal SNP-based PRSs did not vary significantly between males and females. We prioritised three genetic variants whose effect on IPF risk may be modified by sex. These findings would not account for the differences in prevalence between males and females. Future studies should ensure adequate representation of both sexes.
Authors
- William A. Fahy (ORCID: https://orcid.org/0000-0002-1018-0848)
- Imre Noth (ORCID: https://orcid.org/0000-0001-9846-5030)
- Justin M. Oldham (ORCID: https://orcid.org/0000-0003-4957-8869)
- Tasha E. Fingerlin (ORCID: https://orcid.org/0000-0002-6405-3705)
- Simon P. Hart (ORCID: https://orcid.org/0000-0003-4606-9559)
- Anne F Goemans (ORCID: https://orcid.org/0009-0004-4014-4735)
- Gísli Jenkins (ORCID: https://orcid.org/0000-0002-7929-2119)
- Ira M. Hall (ORCID: https://orcid.org/0000-0003-4442-6655)
- Ann Millar
- Tamara Hernández-Beeftink
- Helen Parfrey (ORCID: https://orcid.org/0000-0002-4515-5634)
- Martin D. Tobin (ORCID: https://orcid.org/0000-0002-3596-7874)
- Helen Booth
- Gauri Saini (ORCID: https://orcid.org/0000-0002-7786-737X)
- Robin J. McAnulty (ORCID: https://orcid.org/0000-0003-1936-4245)
- Nik Hirani (ORCID: https://orcid.org/0000-0001-8854-3605)
- Brian L. Yaspan (ORCID: https://orcid.org/0000-0002-3787-2510)
- María Molina‐Molina (ORCID: https://orcid.org/0000-0002-1852-1723)
- Carlos Flores (ORCID: https://orcid.org/0000-0001-5352-069X)
- Toby M. Maher (ORCID: https://orcid.org/0000-0001-7192-9149)
- Louise V. Wain (ORCID: https://orcid.org/0000-0003-4951-1867)
- Philip L. Molyneaux (ORCID: https://orcid.org/0000-0003-1301-8800)
- Amy Stockwell
- Harvinder S Virk (ORCID: https://orcid.org/0000-0002-9739-9593)
- Ayodeji Adegunsoye (ORCID: https://orcid.org/0000-0002-7015-9610)
- Richard J. Allen (ORCID: https://orcid.org/0000-0002-8450-3056)
- Shwu‐Fan Ma (ORCID: https://orcid.org/0000-0002-3058-9480)
- Mary E. Strek (ORCID: https://orcid.org/0000-0002-7671-1023)
- Vidya V. Navaratnam (ORCID: https://orcid.org/0000-0002-2914-8012)
- Moira K. B. Whyte (ORCID: https://orcid.org/0000-0001-7788-1852)
- Olivia C. Leavy (ORCID: https://orcid.org/0000-0002-1503-5535)
- Margaret Neighbors (ORCID: https://orcid.org/0000-0001-7036-7316)
- Carl Reynolds (ORCID: https://orcid.org/0000-0002-7415-258X)
- Ian Sayers (ORCID: https://orcid.org/0000-0001-5601-5410)
- Naftali Kaminski (ORCID: https://orcid.org/0000-0001-5917-4601)
- Beatriz Guillén‐Guío (ORCID: https://orcid.org/0000-0002-3703-1738)
- David A. Schwartz (ORCID: https://orcid.org/0000-0001-6743-8443)
- Yingze Zhang (ORCID: https://orcid.org/0000-0001-6947-2901)
- Fernando J. Martínez (ORCID: https://orcid.org/0000-0002-2412-3182)
- Mike Hill
- X Rebecca Sheng (ORCID: https://orcid.org/0000-0002-9310-6028)
Institutions
- University of Southern California (US)
- University College London Hospitals NHS Foundation Trust (GB)
- University of Nottingham (GB)
- University of Leicester (GB)
- University of Pittsburgh (US)
- The University of Western Australia (AU)
- University of Hull (GB)
- Cornell University (US)
- University of Michigan (US)
- Instituto de Salud Carlos III (ES)
- Bellvitge University Hospital (ES)
- Sir Charles Gairdner Hospital (AU)
- National Jewish Health (US)
- Yale University (US)
- University of Bristol (GB)
- University of Illinois Chicago (US)
- University of Oxford (GB)
- University of Chicago (US)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Hospital Universitario Nuestra Señora de Candelaria (ES)
- Universidad Fernando Pessoa Canarias (ES)
- Royal Brompton Hospital (GB)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Instituto Tecnológico y de Energías Renovables (ES)
- Papworth Hospital NHS Foundation Trust (GB)
- NIHR Imperial Biomedical Research Centre (GB)
- Nottingham Biomedical Research Centre (GB)
- Institute for Respiratory Health (AU)
- NIHR Leicester Biomedical Research Centre (GB)
- Weill Cornell Medicine (US)
- University College London (GB)
- Imperial College London (GB)
- University of Virginia (US)
- Universitat de Barcelona (ES)
- University of Colorado Denver (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1183/23120541.00200-2025
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Ministerio de Ciencia e Innovación
- National Institutes of Health
- Medical Research Council
- Instituto de Salud Carlos III
- National Heart, Lung, and Blood Institute