Effects of inhaled bronchodilators on dynamic lung mechanics during exercise in COPD: protocol for a randomised, placebo-controlled crossover trial
Confirmation of the study's hypotheses will shed new light on the mechanisms of dyspnoea improvement after inhaled bronchodilators in patients with COPD. Moreover, it will provide a novel integrative platform for assessing the effects of therapeutic approaches targeting their small airways.
Authors
- Alessandro Porcella
- Matthew D. James (ORCID: https://orcid.org/0000-0003-1586-6897)
- Nicolle Jasmin Domnik (ORCID: https://orcid.org/0000-0001-6883-4720)
- Denis E. O’Donnell (ORCID: https://orcid.org/0000-0001-7593-2433)
- José Alberto Neder (ORCID: https://orcid.org/0000-0002-8019-281X)
- Guilherme Dionir Back (ORCID: https://orcid.org/0000-0002-1169-8972)
- Reginald M. Smyth
- Sandra G. Vincent
- Abed Hijleh (ORCID: https://orcid.org/0009-0000-1012-0055)
- Karam Alosta
Institutions
- Universidade Federal de São Carlos (BR)
- Queen's University (CA)
- Health First (US)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1183/23120541.01323-2024
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Queen's University
- University of California, Los Angeles