DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features
Burkitt lymphoma can be divided into two epigenetic subtypes (epitypes), each carrying distinct biological, transcriptomic, genomic, and clinical features. Epitype is more strongly associated with clinical and mutational features than the Epstein-Barr virus status or genetic subtype, highlighting an important additional layer of Burkitt lymphoma pathogenesis.
Authors
- Jeremy S. Abramson (ORCID: https://orcid.org/0000-0001-8467-9257)
- Alexandra Traverse‐Glehen (ORCID: https://orcid.org/0000-0002-3934-0120)
- Alina S. Gerrie (ORCID: https://orcid.org/0000-0003-4727-1425)
- Julie M. Gastier‐Foster (ORCID: https://orcid.org/0000-0001-7141-8031)
- Manel Esteller (ORCID: https://orcid.org/0000-0003-4490-6093)
- Laura K. Hilton (ORCID: https://orcid.org/0000-0002-6413-6586)
- Ariela Noy (ORCID: https://orcid.org/0000-0002-3001-4898)
- Nancy L. Harris (ORCID: https://orcid.org/0000-0001-6661-4249)
- David W. Scott (ORCID: https://orcid.org/0000-0002-0435-5947)
- Steven H. Swerdlow (ORCID: https://orcid.org/0000-0002-3832-3329)
- Louis M. Staudt (ORCID: https://orcid.org/0000-0002-1735-2892)
- Jeffrey Bethony (ORCID: https://orcid.org/0000-0002-7901-2113)
- Jackson Orem (ORCID: https://orcid.org/0000-0002-5366-9010)
- Nicholas B. Griner
- Hilary Petrello
- Jay Bowen (ORCID: https://orcid.org/0000-0001-6861-9043)
- Timothy C. Greiner (ORCID: https://orcid.org/0000-0003-1470-8328)
- Charles Grenfell Mullighan (ORCID: https://orcid.org/0000-0002-1871-1850)
- Wyndham H. Wilson (ORCID: https://orcid.org/0000-0002-2862-9711)
- Maureen A. Dyer (ORCID: https://orcid.org/0000-0002-0681-3665)
- Andrew J. Mungall (ORCID: https://orcid.org/0000-0002-0905-2742)
- Sam M. Mbulaiteye (ORCID: https://orcid.org/0000-0002-8273-9831)
- Marco A. Marra (ORCID: https://orcid.org/0000-0001-7146-7175)
- Constance Namirembe (ORCID: https://orcid.org/0000-0001-5979-8465)
- Thomas G. Gross (ORCID: https://orcid.org/0000-0001-5003-6843)
- German Ott (ORCID: https://orcid.org/0000-0001-7990-6793)
- Fábio E. Leal
- Nancy L. Bartlett (ORCID: https://orcid.org/0000-0001-8470-394X)
- Ryan D. Morin (ORCID: https://orcid.org/0000-0003-2932-7800)
- Martin Ogwang (ORCID: https://orcid.org/0000-0002-4178-2809)
- Corey Casper (ORCID: https://orcid.org/0000-0002-3609-661X)
- Carlos Antonio García-Prieto (ORCID: https://orcid.org/0000-0001-5021-6916)
- Elaine S. Jaffe (ORCID: https://orcid.org/0000-0003-4632-0301)
- Kostiantyn Dreval (ORCID: https://orcid.org/0000-0002-6214-2843)
- Steven J. Reynolds (ORCID: https://orcid.org/0000-0002-5403-2759)
- Anthony C. Bryan (ORCID: https://orcid.org/0009-0005-9352-3162)
- Karen Mungall (ORCID: https://orcid.org/0000-0002-9092-4391)
- John D. Irvin
- Nicole Thomas
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Global Forum for Health Research (CH)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- St. Jude Children's Research Hospital (US)
- Nationwide Children's Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of British Columbia (CA)
- University of Pittsburgh (US)
- University of the District of Columbia (US)
- Simon Fraser University (CA)
- Baylor College of Medicine (US)
- Cornell University (US)
- University of Missouri–St. Louis (US)
- Barcelona Supercomputing Center (ES)
- Spinal Cord Injury BC (CA)
- Massachusetts General Hospital (US)
- Josep Carreras Leukaemia Research Institute (ES)
- St. Mary's Hospital Lacor (UG)
- Hôpital Lyon Sud (FR)
- Department of Physiological Sciences (RU)
- Uganda Cancer Institute (UG)
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
- Frederick National Laboratory for Cancer Research (US)
- Canada's Michael Smith Genome Sciences Centre (CA)
- National Institute of Allergy and Infectious Diseases (US)
- Inaccess (Greece) (GR)
- National Cancer Institute (US)
- Instituto Nacional de Câncer - INCA (BR)
- Gulu Hospital (UG)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- The Ohio State University (US)
- University of Nebraska Medical Center (US)
- Universitat Politècnica de Catalunya (ES)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1158/2643-3230.bcd-24-0240
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- U.S. Department of Health and Human Services
- Amgen
- Pfizer
- Gilead Sciences
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- St. Jude Children's Research Hospital
- Fundación Cellex
- TG Therapeutics
- Canada's Michael Smith Genome Sciences Centre
- Incyte
- Michael Smith Health Research BC
- Terry Fox Research Institute
- Ministerio de Ciencia e Innovación
- MorphoSys
- EUSA Pharma
- National Institutes of Health
- Pharmacyclics
- Canadian Institutes of Health Research
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- NHLBI Division of Intramural Research