Circulating immune cells exhibit distinct traits linked to metastatic burden in breast cancer
Our study provides a comprehensive single-cell molecular profile of the peripheral immune system in breast cancer, offering a valuable resource for understanding metastatic disease in terms of tumour burden. By identifying immune traits linked to metastasis, we have unveiled potential new biomarkers of metastatic disease.
Authors
- Lisa A. Mielke (ORCID: https://orcid.org/0000-0002-9522-9320)
- Belinda Yeo (ORCID: https://orcid.org/0000-0002-9218-9917)
- Chaim M. Bell (ORCID: https://orcid.org/0000-0002-3778-9469)
- John M. Mariadason (ORCID: https://orcid.org/0000-0001-9123-7684)
- Simone Ostrouska (ORCID: https://orcid.org/0000-0001-7582-3990)
- Chenyang Zhan (ORCID: https://orcid.org/0000-0003-0062-887X)
- Sadanand Vodala
- Jérémy Berthelet
- Robert Brown (ORCID: https://orcid.org/0000-0001-7960-5755)
- Anthony T. Papenfuss (ORCID: https://orcid.org/0000-0002-1102-8506)
- Andreas Behren (ORCID: https://orcid.org/0000-0001-5329-280X)
- Vijay K. Yadav
- Yunshun Chen (ORCID: https://orcid.org/0000-0003-4911-5653)
- Stefano Mangiola (ORCID: https://orcid.org/0000-0001-7474-836X)
- Simon Chang‐Hao Tsao (ORCID: https://orcid.org/0000-0002-9654-359X)
- Bhupinder Pal (ORCID: https://orcid.org/0000-0002-3684-4331)
- Jacob N. Schroder (ORCID: https://orcid.org/0000-0001-5836-7284)
- Mira Merdas
- Robin L. Anderson (ORCID: https://orcid.org/0000-0002-6841-7422)
- Sonia Guleria (ORCID: https://orcid.org/0000-0003-1230-3968)
- James A. Wilcox
- Chandika Liyanage
- Diana M. Merino (ORCID: https://orcid.org/0009-0001-4086-8125)
- Paula Fuge-Larsen
Institutions
- Rutgers, The State University of New Jersey (US)
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- La Trobe University (AU)
- Peter Doherty Institute (AU)
- Centre for Cancer Biology (AU)
- Olivia Newton-John Cancer Wellness & Research Centre (AU)
- Boehringer Ingelheim (United States) (US)
- Austin Health (AU)
- Rutgers New Jersey Medical School (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s13058-025-01982-2
- Citations
- 2
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Victorian Cancer Agency
- Marshfield Clinic Research Foundation
- National Breast Cancer Foundation
- State Government of Victoria
- Love Your Sister
- Lorenzo and Pamela Galli Charitable Trust
- Medical Research Council
- National Health and Medical Research Council