Long-term stability strategies of deep brain flexible neural interface
Flexible deep brain neural interfaces, as an important research direction in the field of neural engineering, have broad application prospects in areas such as neural signal detection, treatment of neurological diseases, and intelligent control systems. However, chronic inflammatory responses caused by long-term implantation and the resulting electrode failure seriously hinder the clinical development of this technology. This review systematically explores the long-term stability issues of flexible deep brain neural interfaces, with a focus on analyzing the synergistic optimization of electrode geometric morphology and implantation strategies in regulating inflammatory responses. Additionally, this paper delves into innovative strategies, such as passive enhancement of biocompatibility through electrode surface functionalization and active inhibition of inflammation through drug-controlled release systems, offering new technical paths to extend electrode lifespan. By integrating and reviewing existing innovative methods for deep brain flexible electrodes, this study provides an important theoretical foundation and technical guidance for the development of high-stability neural interface devices.
Authors
- Yaoyao Liu (ORCID: https://orcid.org/0009-0009-5775-101X)
- Jinping Luo (ORCID: https://orcid.org/0000-0002-7900-9512)
- Mixia Wang (ORCID: https://orcid.org/0000-0002-1310-8075)
- Shiya Lv (ORCID: https://orcid.org/0000-0001-7412-9294)
- Mingchuan Wang (ORCID: https://orcid.org/0000-0002-9867-258X)
- Qianli Jia
- Yu Liu (ORCID: https://orcid.org/0000-0002-4191-5974)
- Yilin Song (ORCID: https://orcid.org/0000-0002-9490-2237)
- Zhaojie Xu (ORCID: https://orcid.org/0000-0003-1478-6115)
- Siyu Zhang (ORCID: https://orcid.org/0009-0004-3884-648X)
- Yimin Duan (ORCID: https://orcid.org/0000-0002-2675-3524)
- Luyi Jing (ORCID: https://orcid.org/0000-0001-9795-4617)
- Yu Wang (ORCID: https://orcid.org/0000-0001-9407-8375)
- Yirong Wu
- Juntao Liu (ORCID: https://orcid.org/0000-0002-5368-398X)
- Fan Mo (ORCID: https://orcid.org/0000-0002-0881-0062)
- Shan Jin (ORCID: https://orcid.org/0000-0002-2343-9134)
- Xinxia Cai (ORCID: https://orcid.org/0000-0001-5997-7252)
Institutions
- Chinese Academy of Sciences (CN)
- State Key Laboratory of Transducer Technology (CN)
- Aerospace Information Research Institute (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- npj Flexible Electronics
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1038/s41528-025-00410-x
- Citations
- 33
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 30.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- National Key Research and Development Program of China