Breast Angiosarcoma (Case Report)

Primary angiosarcoma (SA) of the breast is a rare neoplasia unrelated to radiation exposure. It represents less than 0.05% of all malignant tumors of the breast. This lesion is characterized by aggressive patterns and a poor prognosis, and by the absence of typical features on radiological examination. Currently, there are no evidence-based guidelines for surgical and adjuvant treatment for this tumor, although wide surgical resection followed by chemotherapy appears to improve disease-free and overall survival. We report a case of primary angiosarcoma in 67-year-old women, without prior radiotherapy, treated with total mastectomy followed by radiochemotherapy. Total mastectomy appears to be the only known treatment that proved useful. Adjuvant therapy has not been proven to date. The 5-year disease-free survival for first-year tumors can be as high as 76%, and as low as 15% for third-year tumors. Because of the rarity of these tumors, there is no standard therapeutic approach.