A pathway toward clinical translation of hyperpolarized [1,4‐<scp><sup>13</sup>C<sub>2</sub></scp>,2,3‐d<sub>2</sub>]fumarate as an imaging biomarker for early cellular necrosis in vivo
HP <sup>13</sup>C-fumarate has shown promise as a novel and safe hyperpolarized agent for monitoring cellular necrosis. This work provides the basis for future imaging of HP <sup>13</sup>C-fumarate metabolism in humans.
Authors
- Otso Arponen (ORCID: https://orcid.org/0000-0002-8541-0126)
- Helen Sladen
- Nikolaj Bøgh (ORCID: https://orcid.org/0000-0002-0321-3269)
- Elizabeth Latimer
- Ian B. Wilkinson (ORCID: https://orcid.org/0000-0001-6598-9399)
- Kevin Michael Brindle (ORCID: https://orcid.org/0000-0003-3883-6287)
- Funan Tan (ORCID: https://orcid.org/0000-0002-9646-2466)
- Johann Graggaber
- Joan Boren
- Joseph Cheriyan (ORCID: https://orcid.org/0000-0001-6921-1592)
- Mary A. McLean (ORCID: https://orcid.org/0000-0002-3752-0179)
- Ines Horvat‐Menih (ORCID: https://orcid.org/0000-0002-1373-6944)
- Anita Chhabra (ORCID: https://orcid.org/0000-0002-9899-8010)
- Ferdia A. Gallagher (ORCID: https://orcid.org/0000-0003-4784-5230)
- Eleni Pappa (ORCID: https://orcid.org/0000-0003-2214-5625)
- Marta Wylot
- Jonathan R. Birchall (ORCID: https://orcid.org/0000-0003-3920-4038)
- Mikko I. Kettunen (ORCID: https://orcid.org/0000-0002-2004-660X)
- Esben Søvsø Szocska Hansen (ORCID: https://orcid.org/0000-0001-5512-9870)
- M. Locke (ORCID: https://orcid.org/0000-0003-3481-2691)
- Christoffer Laustsen (ORCID: https://orcid.org/0000-0002-0317-2911)
- Lotte Bonde Bertelsen (ORCID: https://orcid.org/0000-0002-2491-3184)
- Ashley Grimmer (ORCID: https://orcid.org/0000-0001-6013-5271)
- Pascal Wodtke (ORCID: https://orcid.org/0000-0002-6109-4261)
- Maria Jesus Zamora Morales
- Kelly A. Holmes
Institutions
- AstraZeneca (United Kingdom) (GB)
- University of Eastern Finland (FI)
- Aarhus University (DK)
- University of Cambridge (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Cancer Research UK Cambridge Center (GB)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1002/mrm.30519
- Citations
- 1
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.76
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Department of Health and Social Care
- Cambridge Trust
- Gates Cambridge Trust
- NIHR Cambridge Biomedical Research Centre
- Cancer Research UK Cambridge Institute, University of Cambridge