Tanshinone IIA reduces tubulointerstitial fibrosis by suppressing GSDMD-mediated pyroptosis
Tan IIA may mitigate GSDMD-mediated pyroptosis in renal tubular epithelial cells (RTECs) and reduce kidney fibrosis, highlighting its potential as a therapeutic strategy to prevent the progression of kidney disease after ureteral obstruction.
Authors
- Lei Zhao (ORCID: https://orcid.org/0000-0003-1263-1742)
- Jurong Yang (ORCID: https://orcid.org/0000-0002-6792-4617)
- Luquan Zheng
- Qinglin Luo
- Chunxuan Wang
- Y Yang (ORCID: https://orcid.org/0000-0002-4066-5037)
- Ke Li (ORCID: https://orcid.org/0000-0002-0459-5377)
- Xueling Yang (ORCID: https://orcid.org/0000-0001-7239-4297)
- Zhifen Wu
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Pharmaceutical Biology
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1080/13880209.2025.2498166
- Citations
- 3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing