<i>kcnb1</i> loss of function in zebrafish causes neurodevelopmental and epileptic disorders associated with γ‐aminobutyric acid dysregulation

We conclude that kcnb1 knockout in zebrafish leads to early onset phenotypic features reminiscent of DEEs, affecting neuronal functions and primarily inhibitory pathways in developing embryonic and larval brains. This study highlights the relevance of this model for investigating developmental neuronal signaling pathways in KCNB1-related DEEs.

Authors

Rima Nabbout (ORCID: https://orcid.org/0000-0001-5877-4074)
Claire Bar (ORCID: https://orcid.org/0000-0003-1489-0211)
Sorana Ciura (ORCID: https://orcid.org/0000-0001-6966-9720)
L. Robichon
Anca Marian
Edor Kabashi (ORCID: https://orcid.org/0000-0003-4118-251X)
Lisa Lehmann
Solène Renault

Institutions

Inserm (FR)
Université Paris Cité (FR)
Institut Necker Enfants Malades (FR)
Assistance Publique – Hôpitaux de Paris (FR)

Publication Details

Journal: Epilepsia
Published: 2025-05-07
DOI: https://doi.org/10.1111/epi.18407
Citations: 3
Primary Topic: Ion channel regulation and function
Type: article
Field-Weighted Citation Impact: 2.42

Funders

Agence Nationale de la Recherche
Fondation pour la Recherche Médicale
Fondation Bettencourt Schueller

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article

kcnb1 loss of function in zebrafish causes neurodevelopmental and epileptic disorders associated with γ‐aminobutyric acid dysregulation

Rima Nabbout, Claire Bar, Sorana Ciura, L. Robichon et al.

May 7, 2025

3 citations

Epilepsia

Ion channel regulation and function

2.42

article

kcnb1 loss of function in zebrafish causes neurodevelopmental and epileptic disorders associated with γ‐aminobutyric acid dysregulation

Rima Nabbout, Claire Bar, Sorana Ciura, L. Robichon, Anca Marian, Edor Kabashi, Lisa Lehmann, Solène Renault

May 7, 2025article en

3 citations

Abstract

We conclude that kcnb1 knockout in zebrafish leads to early onset phenotypic features reminiscent of DEEs, affecting neuronal functions and primarily inhibitory pathways in developing embryonic and larval brains. This study highlights the relevance of this model for investigating developmental neuronal signaling pathways in KCNB1-related DEEs.

EpilepsiaVol. 66(8)

Inserm (FR), Université Paris Cité (FR), Institut Necker Enfants Malades (FR), Assistance Publique – Hôpitaux de Paris (FR)

Agence Nationale de la Recherche, Fondation pour la Recherche Médicale, Fondation Bettencourt Schueller

Life below water

Openalex Percentile: Top 12%

Ion channel regulation and function

2.42

DOI Open Access PDF OpenAlex

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<i>kcnb1</i> loss of function in zebrafish causes neurodevelopmental and epileptic disorders associated with γ‐aminobutyric acid dysregulation — Rima Nabbout, Claire Bar, et al. · Epilepsia (2025) | TGRS Research Map | TGRS