PDRN-like marker DNA shows skin beneficial properties through its single-stranded form

Using marker DNA, this work aimed to clarify which of the 2 conformational states of PDRNs (polydeoxyribonucleotides) as a DNA-based remedy, ssDNA random coil or dsDNA helical form, acts as an active player. The marker DNA solution (BN) was subjected to high temperature, which yielded the thermal-denatured BN solution (BN-H) with the enhanced ssDNA. BN-H exhibited significantly higher beneficial properties. The ssDNA state is responsible for its pharmacological properties.

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Publication Details

Journal
Bioscience Biotechnology and Biochemistry
Published
2025-05-05
DOI
https://doi.org/10.1093/bbb/zbaf067
Citations
1
Primary Topic
Photochromic and Fluorescence Chemistry
Type
article
Field-Weighted Citation Impact
0.52
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article

PDRN-like marker DNA shows skin beneficial properties through its single-stranded form

Hye-Won Lim, Kyu-Earn Kim, Chang‐Jin Lim, Hye-Seung Baek et al.
1 citations
Bioscience Biotechnology and Biochemistry
Photochromic and Fluorescence Chemistry
0.52
article

PDRN-like marker DNA shows skin beneficial properties through its single-stranded form

Hye-Won Lim, Kyu-Earn Kim, Chang‐Jin Lim, Hye-Seung Baek, Yuhua Huang, Hong-Gyum Kim
article en
1 citations

Abstract

Using marker DNA, this work aimed to clarify which of the 2 conformational states of PDRNs (polydeoxyribonucleotides) as a DNA-based remedy, ssDNA random coil or dsDNA helical form, acts as an active player. The marker DNA solution (BN) was subjected to high temperature, which yielded the thermal-denatured BN solution (BN-H) with the enhanced ssDNA. BN-H exhibited significantly higher beneficial properties. The ssDNA state is responsible for its pharmacological properties.

Bioscience Biotechnology and BiochemistryVol. 89(8)
Guilford Technical Community College (US), Kangwon National University (KR), Yonsei University (KR), STR Biotech (South Korea) (KR), Novelis (Canada) (CA)
Openalex Percentile: Top 39%
Photochromic and Fluorescence Chemistry
0.52
DOISourceOpenAlex
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PDRN-like marker DNA shows skin beneficial properties through its single-stranded form — Hye-Won Lim, Kyu-Earn Kim, et al. · Bioscience Biotechnology and Biochemistry (2025) | TGRS Research Map | TGRS