Peak analysis of cell-free RNA finds recurrently protected narrow regions with clinical potential
Our study fills the gap in the current small cfRNA-seq analysis at fragment-scale and builds a bridge to the scientific discovery in cfRNA fragmentomics. We demonstrate the significance of finding low abundant tissue-derived signals in small cfRNA and prove the feasibility for application in liquid biopsy.
Authors
- Minghui Mao (ORCID: https://orcid.org/0000-0003-1645-3920)
- Hanjin Ruan (ORCID: https://orcid.org/0000-0001-8486-2115)
- Zhi John Lu (ORCID: https://orcid.org/0000-0003-4751-9400)
- Efres Belmonte‐Reche (ORCID: https://orcid.org/0000-0002-9327-6182)
- Shaozhen Xing (ORCID: https://orcid.org/0009-0002-3081-3216)
- Yuhuan Tao
- Pengfei Bao (ORCID: https://orcid.org/0009-0001-7346-5840)
- Hongli Ma (ORCID: https://orcid.org/0000-0003-2051-6576)
- Taiwei Wang (ORCID: https://orcid.org/0009-0009-6453-2042)
- Zhengxue Han (ORCID: https://orcid.org/0000-0002-9508-1098)
- Xiaofan Liu (ORCID: https://orcid.org/0000-0002-3046-061X)
- Lizheng Qin (ORCID: https://orcid.org/0000-0002-9742-2458)
- Qing Zhan
- Mengtao Li
Institutions
- Universidad de Granada (ES)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (ES)
- Beijing Obstetrics and Gynecology Hospital (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Genome biology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s13059-025-03590-x
- Citations
- 7
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Capital Medical University
- Tsinghua University
- Peking Union Medical College Hospital
- Beijing Institute of Genomics, Chinese Academy of Sciences
- National Key Research and Development Program of China