Expression of MicroRNA-21 in Chronic Lymphoproliferative Disorders: A Cross-Sectional Study from India

This cross-sectional study evaluated the expression of microRNA-21 (miRNA-21) in patients newly diagnosed with chronic lymphoproliferative disorders (CLPD) at a tertiary hospital in Delhi, India, between April 2023 and April 2024. A total of 26 patients were included and miRNA-21 levels were measured using quantitative PCR. Although overall miRNA-21 expression was elevated in CLPD compared to standard values, statistical significance was observed only in patients with Hodgkin and Non-Hodgkin lymphomas. No significant correlation was found between miRNA-21 expression and clinical staging systems, including Rai, Ann Arbor, and ISS. These findings suggest a potential role for miRNA-21 in lymphoproliferative diagnostics, warranting further studies with larger sample sizes for validation.