Super-Enhancer–Driven LncRNA UNC5B-AS1 Inhibits Inflammatory Phenotypic Transition in Pulmonary Artery Smooth Muscle Cells via Lactylation
Our findings identify SE-driven UNC5B-AS1 as a novel regulatory factor in the hypoxia-induced phenotypic transition of PASMCs and suggest that overexpression of UNC5B-AS1 may represent a promising therapeutic strategy for pulmonary hypertension.
Authors
- Xiaodong Zheng (ORCID: https://orcid.org/0000-0002-6103-9836)
- Xiangming Pang
- Cui Ma (ORCID: https://orcid.org/0000-0001-8413-5284)
- Zitong Meng (ORCID: https://orcid.org/0000-0003-4280-2004)
- Xiangrui Zhu
- Fei Li (ORCID: https://orcid.org/0000-0002-1206-9684)
- Xiaoying Wang (ORCID: https://orcid.org/0000-0001-9822-961X)
- Yuxiang Liu (ORCID: https://orcid.org/0000-0003-1971-396X)
- Yujing Tang
- Yingli Chen (ORCID: https://orcid.org/0000-0003-0937-3375)
- Xiaoyu Guan (ORCID: https://orcid.org/0000-0002-9208-9377)
- Lixin Zhang (ORCID: https://orcid.org/0000-0002-6177-4152)
- Jian Mei
- Langlin Ou
- Zhaosi Wang
Institutions
- Harbin Medical University (CN)
- Xiamen University (CN)
- World Wide Web Consortium (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1161/atvbaha.124.322174
- Citations
- 7
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 6.55