ADAMTS-13 Prevents VWF-Mediated Gastric Cancer Metastasis
We show how VWF becomes hyperadhesive to promote the pulmonary metastasis of gastric cancer through its interaction with gastric cancer-derived extracellular vesicles and that the hyperadhesive activity of VWF is reduced by ADAMTS-13 to prevent the metastasis.
Authors
- Chen-Li Zhang
- Min Li (ORCID: https://orcid.org/0000-0001-6902-7242)
- Jing‐fei Dong (ORCID: https://orcid.org/0000-0001-6379-4133)
- Chan‐yuan Zhao (ORCID: https://orcid.org/0000-0001-9198-8488)
- An-Yong Yang (ORCID: https://orcid.org/0009-0004-7134-3024)
- Jun-Cheng Dong
- Feng-xia Wang
- Xiaoyu Zhang (ORCID: https://orcid.org/0000-0002-0637-5669)
- Quan Zhou (ORCID: https://orcid.org/0009-0001-8505-2779)
- Chen-yu Wang
- Yixuan Dang (ORCID: https://orcid.org/0000-0003-0873-4490)
- Chengzhong Du
- Min Wang (ORCID: https://orcid.org/0000-0002-8905-6857)
Institutions
- Yarsi University (ID)
- University of Washington (US)
- Bloodworks Northwest (US)
- Gansu Provincial Hospital (CN)
- Gansu Provincial Maternal and Child Health Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1161/atvbaha.125.322553
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00