Impaired CAMK4 Activity Limits Atherosclerosis and Reprograms Myelopoiesis
These findings suggest that CaMK4 is an important regulator of the myelopoietic response to hypercholesterolemia through ATF6-mediated transcriptional regulation and that loss of functional CaMK4 promotes a proreparative phenotype in myeloid cells. Therefore, targeting CaMK4 may offer a unique way to target the progression of atherosclerosis.
Authors
- Jesse L. Bonin (ORCID: https://orcid.org/0009-0003-5595-3749)
- Ashley Cavnar (ORCID: https://orcid.org/0000-0001-5081-9274)
- P. Brent Ferrell (ORCID: https://orcid.org/0000-0003-1140-9154)
- A. Wayne Orr (ORCID: https://orcid.org/0000-0002-2377-213X)
- Matthew M Dungan (ORCID: https://orcid.org/0000-0002-2989-5982)
- Meena S. Madhur (ORCID: https://orcid.org/0000-0002-0407-634X)
- Kasey C. Vickers (ORCID: https://orcid.org/0000-0001-5643-3102)
- James Traylor (ORCID: https://orcid.org/0000-0002-7119-6333)
- Kristin Fuller
- Cristina M. Youwakim
- Arif Yurdagul (ORCID: https://orcid.org/0000-0002-7613-6313)
- Shuai Yuan (ORCID: https://orcid.org/0000-0002-9590-6555)
- Zachary A. Kohutek (ORCID: https://orcid.org/0000-0002-2472-9977)
- Lindsay M. Davison (ORCID: https://orcid.org/0000-0001-8387-4958)
- Azuah L. Gonzalez (ORCID: https://orcid.org/0000-0001-6382-5657)
- Katherine C. MacNamara (ORCID: https://orcid.org/0000-0001-6202-4700)
- Brenda F. Leake
- Amanda C. Doran (ORCID: https://orcid.org/0000-0002-1576-6274)
- Yunli E. Chu (ORCID: https://orcid.org/0000-0001-6120-1496)
- MacRae F. Linton (ORCID: https://orcid.org/0000-0002-9277-0453)
- Danielle L. Michell (ORCID: https://orcid.org/0000-0002-2048-4191)
- Jonathan D. Brown (ORCID: https://orcid.org/0000-0002-0359-6167)
- S.M. Jamshedur Rahman (ORCID: https://orcid.org/0009-0000-8866-3957)
- Katherine Gu
- Calliope Cutchins
Institutions
- University of Pittsburgh (US)
- Vanderbilt University (US)
- Indiana University – Purdue University Indianapolis (US)
- Albany Medical Center Hospital (US)
- Louisiana State University Health Sciences Center Shreveport (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1161/atvbaha.125.322530
- Citations
- 2
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.59