Impaired CAMK4 Activity Limits Atherosclerosis and Reprograms Myelopoiesis

These findings suggest that CaMK4 is an important regulator of the myelopoietic response to hypercholesterolemia through ATF6-mediated transcriptional regulation and that loss of functional CaMK4 promotes a proreparative phenotype in myeloid cells. Therefore, targeting CaMK4 may offer a unique way to target the progression of atherosclerosis.

Authors

Institutions

Publication Details

Journal
Arteriosclerosis Thrombosis and Vascular Biology
Published
2025-05-08
DOI
https://doi.org/10.1161/atvbaha.125.322530
Citations
2
Primary Topic
Atherosclerosis and Cardiovascular Diseases
Type
article
Field-Weighted Citation Impact
1.59
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Impaired CAMK4 Activity Limits Atherosclerosis and Reprograms Myelopoiesis

Jesse L. Bonin, Ashley Cavnar, P. Brent Ferrell, A. Wayne Orr et al.
2 citations
Arteriosclerosis Thrombosis and Vascular Biology
Atherosclerosis and Cardiovascular Diseases
1.59
article

Impaired CAMK4 Activity Limits Atherosclerosis and Reprograms Myelopoiesis

Jesse L. Bonin, Ashley Cavnar, P. Brent Ferrell, A. Wayne Orr, Matthew M Dungan, Meena S. Madhur, Kasey C. Vickers, James Traylor, Kristin Fuller, Cristina M. Youwakim, Arif Yurdagul, Shuai Yuan, Zachary A. Kohutek, Lindsay M. Davison, Azuah L. Gonzalez, Katherine C. MacNamara, Brenda F. Leake, Amanda C. Doran, Yunli E. Chu, MacRae F. Linton, Danielle L. Michell, Jonathan D. Brown, S.M. Jamshedur Rahman, Katherine Gu, Calliope Cutchins
article en
2 citations

Abstract

These findings suggest that CaMK4 is an important regulator of the myelopoietic response to hypercholesterolemia through ATF6-mediated transcriptional regulation and that loss of functional CaMK4 promotes a proreparative phenotype in myeloid cells. Therefore, targeting CaMK4 may offer a unique way to target the progression of atherosclerosis.

Arteriosclerosis Thrombosis and Vascular BiologyVol. 45(7)
University of Pittsburgh (US), Vanderbilt University (US), Indiana University – Purdue University Indianapolis (US), Albany Medical Center Hospital (US), Louisiana State University Health Sciences Center Shreveport (US), Vanderbilt University Medical Center (US)
Good health and well-being
Openalex Percentile: Top 17%
Atherosclerosis and Cardiovascular Diseases
1.59
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.