Relevance of choroid plexus volumes in multiple sclerosis
Our analysis confirmed that the ChP was significantly enlarged in patients with RRMS, which was related to brain lesion volumes and which suggested a dynamic development as it was associated with disease duration. Plexus enlargement was further associated with periventricular demyelination or tissue damage assessed by T1w/FLAIR ratios in RRMS. Furthermore, we did not find an enlargement of the ChP in patients with PPMS, possibly indicating the reduced involvement of inflammatory processes in the progressive phase of MS. The association between enlarged ChP volumes and cortical atrophy in RRMS highlighted the vulnerability of structures close to the CSF.
Authors
- Carsten Lukas (ORCID: https://orcid.org/0000-0002-8562-9697)
- Tanja Schmitz‐Hübsch
- Theodoros Ladopoulos (ORCID: https://orcid.org/0009-0006-1735-4130)
- Claudia Chien (ORCID: https://orcid.org/0000-0001-8280-9513)
- Ruth Schneider (ORCID: https://orcid.org/0000-0002-0997-2725)
- Ralf Gold (ORCID: https://orcid.org/0000-0002-7223-3052)
- Friedemann Paul
- Rebekka Rust (ORCID: https://orcid.org/0009-0004-9600-7342)
- Zainab Abbas (ORCID: https://orcid.org/0000-0002-2948-7401)
- Britta Krieger
- Barbara Bellenberg (ORCID: https://orcid.org/0000-0001-7484-6787)
- Anna Katharina Roenneke
Institutions
- Max Delbrück Center (DE)
- St. Josef-Hospital (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s12987-025-00656-7
- Citations
- 9
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 13.24