NGHIÊN CỨU CHẾ TẠO VÀ ĐÁNH GIÁ MỘT SỐ CHỈ TIÊU CỦA XỐP CẦM MÁU CẤU TẠO TỪ CHITOSAN

STUDY ON PRODUCTION AND EVALUATION OF CHITOSAN HEMOSTATIC SPONGEThis study presented the results of producing a hemostatic sponge based on chitosan by the freeze-drying method. The morphology, pore size, swelling ratio, in vitro blood clotting test, and in vivo hemostatic assay of the product were evaluated. Results showed the sponge has a uniform porous structure with a pore size range between 40µm and 170µm and a high swelling ratio (23 times). In vitro blood clotting tests show that the sponge has fast blood clotting time (≤ 40 seconds). In vivo studies were conducted on a rat femoral artery injury model, the product was effective in controlling bleeding, stopping bleeding 3.3 times faster, and reducing bleeding volume by 8.5 times compared to the batch using medical gauze.